What are the top Python repos?
Popular Python repositories on GitHub, each answered in plain English for non-coders: what it is, its tech stack, and how to run it.
- umocxzzz/astrbot_plugin_owstats777An Astrbot chat plugin that lets players look up Overwatch 2 stats, match history, and AI-generated coaching f
- wepoets1107/btc-collision-hunterA Python art project that generates Bitcoin private keys and checks for funded wallets — not to find any, but
- wood-q/mokioagentA step by step Python teaching project that grows a minimal AI tool call into a small coding and terminal assi
- wshuyi/zettel-builderA Python tool that converts reading material into a network of atomic note cards using the Zettelkasten method
- x-plug/toolcuaToolCUA is a research AI agent that operates a desktop like a human, choosing between clicking through a GUI a
- yzy1223/jarvisJ.A.R.V.I.S. is a Python multi-agent coding assistant that remembers successful past sessions, turning repeate
- zzyong24/thirdspace-vault-templateA ready-to-clone knowledge base template that lets AI agents like Claude Code and Cursor automatically organiz
- andyuneducated/resolve-aiScaffold of a multi-agent customer-support system with four specialist agents coordinated by LangGraph, five m
- carriex6/cvpr2026_similarity_as_evidenceOfficial CVPR 2026 code that uses BiomedCLIP image similarity to estimate uncertainty in active learning for m
- codejunkie99/familiar-second-brainA local Markdown vault plus MCP server that lets multiple AI assistants share notes and memory across sessions
- coleam00/helplineA pretend B2B helpdesk monorepo that serves as a worked example of an AI Layer (CLAUDE.md hierarchy, hooks, sk
- cuihuan/awesome-ai-gatewayA curated, scored comparison of over 50 AI gateway and LLM proxy tools, including a cost benchmark and a decis
- dakros66/doc-u1-linkA desktop tool that converts 3D print project files from Bambu Studio into a format that works on a Snapmaker
- darkdisaster08/darkbusterA Python command-line tool for authorized security testers to discover hidden web pages, admin panels, and API
- data-context-hq/datacontextPython library that attaches request, user, and trace context to every database query so you can later trace a
- dhruvb14/hacsA collection of custom Home Assistant integrations, starting with one that turns any infrared remote into a sm
- diqiuzhuanzhuan/openllm-func-call-synthesizerPython toolkit that generates, scores, and exports function-calling training datasets for LLMs in multiple lan
- djs0618/rfabeRFABE is a cloud-based medical records system where patient data is encrypted so only users whose job role or
- franckyb/comfyui-dramaboxComfyUI custom nodes that bring DramaBox's expressive text-to-speech AI model into visual generation workflows
- gattaca-com/propammPython and Rust scripts for automatically trading against FermiSwap, Kipseli, and Bebop pools on Ethereum via
- int-brain-lab/ibl-ai-agentA repository that lets neuroscientists use AI coding assistants to explore and analyze International Brain Lab
- ivanfioravanti/fasterliveportrait-mlxAnimate portrait photos and videos on Apple Silicon Macs using AI — feed it a webcam, video, audio, or text to
- jurio0304/codex_automated_paper_readerDaily pipeline that fetches arXiv and OpenReview papers, deduplicates and pre-scores them with Python, then as
- jzb1006/claude-vigilA Python task queue manager that runs Claude Code on a list of tasks unattended, giving each one an isolated g
- kresnapandu/memwatchmemwatch is a Python library that tracks how stale each fact in an AI agent's memory has become, using decay c
- lake121380-source/lakejobai-job-radarA local Python tool that automates job searching, applications, and AI-powered recruiter chat replies on the C
- ldolanldolan/coma-metabolomicsPython tool for metabolomics researchers that reconciles disagreeing chemical annotations from multiple mass-s
- leochlon/ntkmirrorA Python library that teaches an AI language model new behaviors by learning a tiny set of scaling values — no
- lukaszkurowskilbn/polska-faktura-za-pradA Home Assistant add-on that recalculates your Polish electricity bill in real time from editable rate entitie
- lwhfxmoss/sub2api-oauth-sleeper-pluginSidecar plugin for Sub2API that watches OpenAI and Anthropic OAuth account usage and marks accounts rate-limit
- matheuscfrade/arch-flows-visualizerA Python tool that turns JSON architecture data into interactive, clickable HTML diagrams showing system compo
- mlweber/taubenturret-backendA Python backend that uses YOLO and OpenVINO to detect pigeons for an automated deterrent turret system.
- olofsatte/cve-2026-41940-pocA Python proof-of-concept showing a CVSS 10.0 authentication bypass in cPanel and WHM web hosting control pane
- outsourc-e/bench-loopA CLI tool that benchmarks local AI models for speed, accuracy, and tool-use reliability on your own hardware.
- qianzhong-chen/openspiralResearch code that trains a small residual network on top of a frozen pi-zero robot policy so the robot can im
- rookiestar28/comfyui-longcat-avatarThis ComfyUI extension turns a photo and an audio clip into a talking head video by adding support for the Lon
- veronez-io/claude-code-devopsA Node.js news portal demo app used to teach Kubernetes and containers, with built-in endpoints for simulating
- vixues/leagentA self-hosted desktop app where you chat with AI models and build drag-and-drop automation workflows — connect
- vortrix5/siftyA safety-first Windows cleanup tool that scans, previews, and removes junk files, duplicates, and dev clutter
- yolenatch/vocosdevA Python project described as an AI-driven system, Vocos, that automates resource allocation across clusters,
- youstheone/fh6autoA Python automation tool for Forza Horizon 6 on Windows that uses image recognition to run races, buy cars, an
- 0petru/sentimoA Python library that gives AI chat agents a persistent emotional state and Big Five personality — tracking si
- alingalingling/akasha-wechatA Python bridge that connects a personal WeChat account to AI models like DeepSeek or Claude, turning a spare
- amap-cvlab/abot-ocrAn AI model from a computer vision lab that converts scanned document images into structured Markdown, preserv
- atlasomnia/hermes-tool-routerA Python plugin for the Hermes AI agent that predicts which tools a conversation needs and loads only those gr
- auctorai/durable_agentsA runnable demo showing how to make AI agent tool calls durable and retryable by running them as Temporal work
- axbiao/news-stock-selectorA Claude Code skill that reads today's news, finds Chinese A-share stocks mentioned or implied, scores each on
- benleikin/pitimeA DIY GPS based time server for a Raspberry Pi that syncs your local network clock to within microseconds, far
- blackotters/sonicstarA training and deployment toolkit for AI-controlled motion on the Unitree G1 humanoid robot. Give the robot a
- bovod-sjtu/holitokA research library from Shanghai Jiao Tong University that compresses audio files into compact representations
- brainchip-inc/do-transformers-need-3-projectionsResearch code from an ICML 2026 paper showing that merging the key and value projection weights in transformer
- bwr-hhh/tflowTFlow is the official code for a research paper on multi-agent LLMs that share information as temporary LoRA w
- cancelgumu/webotA Windows bot that monitors WeChat group chats, summarizes missed messages on request, answers questions when
- carpedkm/customditA research project (ICASSP 2026) with a dataset, model, and benchmark for generating videos of a specific pers
- chili-lab/lt2Research code for a new language model architecture that replaces slow attention with faster alternatives and
- ctx-0/lazyllamaA command-line tool that scans your computer for locally installed AI language models across HuggingFace, Olla
- daveebbelaar/document-copilotAn AI chatbot that lets you ask plain-English questions about a collection of uploaded PDFs and get sourced an
- epoko77-ai/tokensaveTokensave audits AI agent setups built with Claude Code to find wasted spending, such as using expensive model
- everyinc/hands-on-deckA Python command-line tool that lets AI agents safely edit PowerPoint files through JSON patches instead of ri
- fictionarry/ambisurA research codebase from ICML 2026 that improves 3D surface reconstruction from photos by correcting for photo
- freedomintelligence/sepsisagentA research AI agent that recommends ICU sepsis treatment by simulating patient outcomes with a learned Clinica
- fuyuxiang/patent-disclosure-skillA plug-in skill for AI coding assistants like Claude Code and Cursor that guides inventors through a multi-rou
- he-wei-gui/everythingtohtmlA Python library and CLI that converts PDFs, Word, Excel, EPUB, and other formats into a single self-contained
- icetea-cv/mv-romaA Python research library that finds matching points across multiple photos simultaneously — keeping correspon
- isalia20/metalblasA Python library that replaces PyTorch's matrix multiplication on Apple Silicon Macs with custom Metal GPU cod
- jnmhub/gopay-auto-protocolA Python script that automatically registers GoPay (an Indonesian digital payments app) accounts by buying tem
- kizuna-intelligence/flux2-klein-liteA Python library that compresses the FLUX.2-klein image generation model using 4-bit quantization so it runs o
- lanternko/aram-mayhem-databaseARAM Mayhem Database tracks League of Legends ARAM Mayhem match data that Riot's public API no longer provides
- locuslab/eqrResearch code from Carnegie Mellon that trains neural networks to solve hard reasoning tasks like extreme Sudo
- margetrp-hub/gpt-account-managerA self-hosted Python web app for managing multiple OpenAI and ChatGPT accounts in bulk — it runs OAuth credent
- mattc95/2026-ai-detector-benchmarkA May 2026 benchmark of four commercial AI-text detectors (GPTHumanizer, GPTZero, ZeroGPT, Sapling) on 1,000 b
- mega-edo/mega-tronA shared skill layer for Codex, Claude Code, and Gemini CLI that only loads relevant skills per prompt and tra
- mhiskall282/novice-dev-with-aiA 4-day beginner web development course teaching HTML, CSS, and Flexbox while using AI tools like Claude as gu
- mikuz12/exampass-assistantA Python tool that converts university lecture slides and documents (PPTX, DOCX, PDF) into browser-ready HTML
- mrcarlsama/mrcarlsama-social-transcriber-skillA skill for AI coding agents that downloads a single Douyin or Xiaohongshu video, extracts the audio, transcri
- nanparth/ai-skill-hubA personal collection of nine AI assistant skills covering research, business, legal diagrams, job application
- oranger-l/mgsdA research codebase for training AI models to plan through visual spatial tasks like mazes by learning from bo
- otsolain/geckoA self-hosted passive reconnaissance platform for authorized security testing that runs sequential information
- otsolain/sanguineroseA Python command-line tool for authorized security testing of website registration endpoints — sends batches o
- plntrprotocol/risomorphism-1911ASCII Art Pipeline is a Python command line tool that converts still images and video into high-quality ASCII
- prashant9501/meridian-wealthA Python web app that acts as an AI financial analyst for a wealth management firm, answering questions about
- robot-i-o/rioRIO is a Python interface for controlling many different robot arms, grippers, and cameras through one codebas
- sanguine886/nortsubA Chinese-language tool that automates passwordless ChatGPT logins via email OTP in bulk and converts the resu
- sid2697/hopformerHOPformer is a research model that predicts 3D hand and object positions from a single first-person camera ima
- smyan1909/somaticA tool that lets AI agents control a desktop by detecting and numbering every clickable element on screen, so
- tristan0318/fraudbenchFraudBench is a research benchmark and dataset for testing whether multimodal AI models can detect AI-generate
- yangchuansheng/patch-codex-fastAn unofficial patch that unlocks Fast mode and Plugins in the Codex desktop app for users signed in with an AP
- yczhou001/pf-opsdAn AI research project that teaches language models to reason about spatial puzzles and physical video events
- yisan0429/itranslationA command-line tool that translates whole books into Chinese with AI, using overlapping chunks to avoid cuttin
- yupyanyo/blockchainmA Python framework that combines machine learning tools with decentralized network infrastructure, offering au
- 920linjerry-stack/capital-studioA local financial modeling app for practicing DCF valuation, LBO modeling, and M&A deal simulation, with every
- adya84/ha-world-cup-2026A Home Assistant integration that brings live FIFA World Cup 2026 match data, group standings, knockout bracke
- afk-surf/safeclipperA local privacy filter that OCR-scans screenshots, detects sensitive text like API keys, emails, and account n
- aza-ali/github-readme-crisp-linksCLI and web app that generate SVG text wrapped in a markdown link, removing the underline GitHub adds under RE
- bachovak/end-to-end-pbi-report-w-aiA portfolio project showing how an AI coding assistant built a full Power BI supplier delivery dashboard witho
- bjvgukv25842-cmyk/pixelclone-skillPixelClone Skill is a set of instructions for AI coding assistants that forces them to copy a website design f
- chenruishuo/posterlyA tool that creates academic conference posters using HTML and CSS instead of LaTeX, then converts them to pri
- clearyss/weloomA local-first tool that turns exported chat history into a searchable memory system and an AI companion that t
- crazymsn/academic-shcolar-skillsA suite of AI agent workflows that guides a research paper from literature review through writing, peer review
- ddunaev247/polymarket-auto-teak-profit-bot-btc-5min-up-downAn automated take-profit bot for Polymarket prediction markets that monitors your open trades every five secon
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